The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
A brief survey on the application of metal-catalyzed azide–alkyne cycloaddition reactions to the synthesis of ferrocenyl-x-1, 2, 3-triazolyl-R (x= none or a linker and R …
K Kowalski - Coordination Chemistry Reviews, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide. This review highlights the
importance of metal-catalyzed azide–alkyne cycloaddition reactions in the synthesis of …
importance of metal-catalyzed azide–alkyne cycloaddition reactions in the synthesis of …
[HTML][HTML] β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer
Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal
growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase …
growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase …
Recent advances in boosting EGFR tyrosine kinase inhibitors-based cancer therapy
Q Pan, Y Lu, L Xie, D Wu, R Liu, W Gao… - Molecular …, 2023 - ACS Publications
Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …
A Potential Boron Neutron Capture Therapy Agent Selectively Suppresses High-Grade Glioma: In Vitro and in Vivo Exploration
C Alamón, B Dávila, MF García, S Nievas… - Molecular …, 2023 - ACS Publications
Glioblastoma (GBM), as the most central nervous system (CNS) intractable disease, has
spoiled millions of lives due to its high mortality. Even though several efforts have been …
spoiled millions of lives due to its high mortality. Even though several efforts have been …
Electronic coupling in 1, 2, 3-triazole bridged ferrocenes and its impact on reactive oxygen species generation and deleterious activity in cancer cells
P Biegański, E Kovalski, N Israel, E Dmitrieva… - Inorganic …, 2022 - ACS Publications
Mixed-valence (MV) binuclear ferrocenyl compounds have long been studied as models for
testing theories of electron transfer and in attempts to design molecular-scale electronic …
testing theories of electron transfer and in attempts to design molecular-scale electronic …
Benzothiazole-tethered 1, 2, 3-triazoles: synthesis, antimicrobial, antioxidant, and molecular docking studies
T El Malah, MI Hegab, HM Awad… - Journal of Molecular …, 2022 - Elsevier
Over the past decades, antibiotic resistance has garnered considerable attention as a public
health concern. Therefore, it has become necessary to develop new generations of …
health concern. Therefore, it has become necessary to develop new generations of …
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents
X Ma, Z Wang, Y Li, Y Wang… - Medicinal Research …, 2024 - Wiley Online Library
Overexpression of the epidermal growth factor receptor (EGFR, erbB1) has been observed
in a wide range of solid tumors and has frequently been associated with poor prognosis. As …
in a wide range of solid tumors and has frequently been associated with poor prognosis. As …
Structural Modification Strategies of Triazoles in Anticancer Drug Development
Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …
potent anticancer activities, including numerous clinically approved drugs. The strategic …
Erlotinib-containing benzenesulfonamides as anti-Helicobacter pylori agents through carbonic anhydrase inhibition
G Benito, I D'Agostino, S Carradori… - Future Medicinal …, 2023 - Future Science
Aim: Development of dual-acting antibacterial agents containing Erlotinib, a recognized
EGFR inhibitor used as an anticancer agent, with differently spaced benzenesulfonamide …
EGFR inhibitor used as an anticancer agent, with differently spaced benzenesulfonamide …