The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …

In contrast to adaptive antibodies, natural antibodies are present in a non-immunised
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …

Natural IgM are highly represented in the circulation at birth, and these often autoreactive
antibodies have been postulated to have innate-like properties and play crucial roles in …

Natural Abs, which arise without known immune exposure, have been described that
specifically recognize cells dying from apoptosis, but their role in innate immunity remains …

Recently, a polymorphism in the complement regulator factor H (FH) gene has been
associated with age-related macular degeneration. When histidine instead of tyrosine is …

B1 lymphocytes may be subdivided by CD5 and CD11b/Mac1 expression into B1a, with the
CD5 and CD11b/Mac1 phenotype, and B1b, which present as CD19 hi CD5 lo CD11b hi …

C-reactive protein (CRP) is the major acute phase protein in humans. It has been shown that
CRP interacts with factor H, an inhibitor of the alternative pathway of complement, and now …

The molecular and functional characteristics of natural antibody from the preimmune
repertoire have not been explored in detail in man. We describe seven human IgM …

The adaptive immune system augments host defenses against diverse infectious threats, yet
also carries intertwined risks for the development of autoimmune disease. The immune …