[HTML][HTML] RNA m6A modifications in mammalian gametogenesis and pregnancy

X Sui, A Klungland, L Gao - Reproduction, 2023 - rep.bioscientifica.com
In brief RNA modifications play key roles in regulating various biological processes. This
article discusses and summarizes the recent advances of RNA m6A modifications related to …

[HTML][HTML] Genetic regulation of N6-methyladenosine-RNA in mammalian gametogenesis and embryonic development

Y Chang, M Yi, J Wang, Z Cao, T Zhou, W Ge… - Frontiers in cell and …, 2022 - frontiersin.org
Emerging evidence shows that m6A is the most abundant modification in eukaryotic RNA
molecules. It has only recently been found that this epigenetic modification plays an …

Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an m6A-dependent manner

W Fan, W Zhou, Q Yan, Y Peng, H Wang, C Kong… - Placenta, 2022 - Elsevier
Introduction Preeclampsia, a specific complication of pregnancy, is a leading cause of
perinatal and maternal mortality worldwide. N 6-methyladenosine (m 6 A) is a prevalent and …

[HTML][HTML] m 6A methylation in cellular senescence of age-associated diseases: m 6A methylation in cellular senescence of age-associated diseases

P Gao, F Yao, J Pang, K Yin, X Zhu - Acta Biochimica et Biophysica …, 2023 - ncbi.nlm.nih.gov
Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to
various stresses. In addition to exiting the cell cycle, senescent cells undergo many …

Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryos

Y Shi, P Zhao, Y Dang, S Li, L Luo, B Hu… - Biology of …, 2021 - academic.oup.com
Upon fertilization, extensive chromatin reprogramming occurs during preimplantation
development. Growing evidence reveals species-dependent regulations of this process in …

Transcriptome‐wide analysis of mRNA N6‐methyladenosine modification in the embryonic development of Spodoptera frugiperda

Y Chen, Y Lai, R Liu, L Yao, XQ Yu, X Wang - Insect Science, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) RNA is the most abundant modification of mRNA, and
has been demonstrated in regulating various post‐transcriptional processes. Many studies …

Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos

L Zhang, M Yuan, X Huang, Q Cao, S Huang… - …, 2022 - rep.bioscientifica.com
In brief Several factors affect the reprogramming efficiency of nuclear transfer embryos. This
study shows that inhibiting 18S rRNA m 6 A methyltransferase METTL5 during nuclear …

Prognostic score model based on six m6A‐related autophagy genes for predicting survival in esophageal squamous cell carcinoma

F Chen, E Gong, J Ma, J Lin, C Wu… - Journal of Clinical …, 2022 - Wiley Online Library
Background Prognostic signatures based on autophagy genes have been proposed for
esophageal squamous cell carcinoma (ESCC). Autophagy genes are closely associated …

METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner

Y Sun, XC Zhang, MD Li, LG Bu, B Wang… - Biology of …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A), an epigenetic modification on RNAs, plays an
important role in many physiological and pathological processes. However, the involvement …

[HTML][HTML] Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani-Induced Keratitis via the NF-κB Signaling Pathway

H Tang, L Huang, J Hu - Investigative Ophthalmology & Visual …, 2022 - iovs.arvojournals.org
Purpose: The purpose of this study was to elucidate the effect of methyltransferase-like
enzyme 3 (METTL3) on inflammation and the NF-κB signaling pathway in fungal keratitis …