Recently, many therapeutic agents for prostate cancer have been approved that target the
androgen receptor and/or the prostate tumor microenvironment. Each of these therapies has …

Peter Nowell and David Hungerford's discovery of the Philadelphia chromosome facilitated
many critical studies that have led to a paradigm shift in our understanding of cancer as a …

The murine Pten prostate cancer model described in this study recapitulates the disease
progression seen in humans: initiation of prostate cancer with prostatic intraepithelial …

Androgen receptor (AR) plays a central role in prostate cancer, with most tumors responding
to androgen deprivation therapies, but the molecular basis for this androgen dependence …

Prostate cancer patients with regional lymph node involvement at radical prostatectomy
often experience disease progression to other organs, with the bone as the predominant …

PTEN mutations are among the most frequent genetic alterations found in human prostate
cancers. Our previous works suggest that although precancerous lesions were found in Pten …

Abstract KDM5B (lysine [K]-specific demethylase 5B) is frequently upregulated in various
human cancers including prostate cancer. KDM5B controls H3K4me3/2 levels and regulates …

The aberrant behavior of cancer reflects upregulation of certain oncogenic signaling
pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and …

The development and optimization of high‐throughput screening methods has identified a
multitude of genetic changes associated with human disease. The use of immunodeficient …

SIRT1, an NAD-dependent histone/protein deacetylase, has classically been thought of as a
nuclear protein. In this study, we demonstrate that SIRT1 is mainly localized in the nucleus of …