The chemokine system coordinates leukocyte migration in immunity and inflammation and is
implicated in the pathogenesis of many human diseases. Although several successful …

Lymphocytes are intrinsically mobile and circulate continuously between the blood and
secondary lymphoid tissues. When naive lymphocytes first enter lymph nodes and Peyer's …

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are …

Directional guidance of cells via gradients of chemokines is considered crucial for
embryonic development, cancer dissemination, and immune responses. Nevertheless, the …

After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the
paracortex, with each lymphocyte type showing apparently random migration within these …

Interactions between B and T cells are essential for most antibody responses, but the
dynamics of these interactions are poorly understood. By two-photon microscopy of intact …

Intrathymic expression of tissue-specific antigens (TSAs) by medullary thymic epithelial cells
(Mtecs) leads to deletion of autoreactive T cells. However, because Mtecs are known to be …

The adaptive immune response is initiated in secondary lymphoid organs by contact
between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+ T cells. However …

Chemokines are a large family of small, generally secreted polypeptides which guide
lymphocyte movement throughout the body by controlling integrin avidity and inducing …

The visualization of the dynamic behaviour of and interactions between immune cells using
time-lapse video microscopy has an important role in modern immunology. To draw robust …