Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Crystal polymorphism in chemical process development
AY Lee, D Erdemir, AS Myerson - Annual review of chemical …, 2011 - annualreviews.org
Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …
[图书][B] Polymorphism in molecular crystals 2e
J Bernstein - 2020 - books.google.com
Most people are familiar with the fact that diamond and graphite are both composed only of
carbon; yet they have very different properties which result from the very different structures …
carbon; yet they have very different properties which result from the very different structures …
Polymorphism in pharmaceutical solids
HG Brittain - Drugs and the pharmaceutical sciences, 1999 - api.taylorfrancis.com
It is now just about 10 years since the publication of the first edition of Polymorphism in
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …
[HTML][HTML] A practical guide to pharmaceutical polymorph screening & selection
EH Lee - Asian Journal of Pharmaceutical Sciences, 2014 - Elsevier
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are
well recognized. It is of great importance to prepare and select the right form from the …
well recognized. It is of great importance to prepare and select the right form from the …
Conformational polymorphism in organic crystals
A Nangia - Accounts of chemical research, 2008 - ACS Publications
Polymorphs are different crystalline modifications of the same chemical substance. When
different conformers of the same molecule occur in different crystal forms, the phenomenon …
different conformers of the same molecule occur in different crystal forms, the phenomenon …
Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review
YC Shen - International journal of pharmaceutics, 2011 - Elsevier
The terahertz region of the electromagnetic spectrum spans the frequency range between
the infrared and the microwave. Traditionally the exploitation of this spectral region has been …
the infrared and the microwave. Traditionally the exploitation of this spectral region has been …
[HTML][HTML] Pharmaceutical cocrystals: regulatory and strategic aspects, design and development
DD Gadade, SS Pekamwar - Advanced pharmaceutical bulletin, 2016 - ncbi.nlm.nih.gov
Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive
interest of researchers from pharmaceutical and chemical sciences and of drug regulatory …
interest of researchers from pharmaceutical and chemical sciences and of drug regulatory …
Pharmaceutical hydrates analysis—overview of methods and recent advances
E Jurczak, AH Mazurek, Ł Szeleszczuk, DM Pisklak… - Pharmaceutics, 2020 - mdpi.com
This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …
Applications of powder X-ray diffraction in small molecule pharmaceuticals: achievements and aspirations
NK Thakral, RL Zanon, RC Kelly, S Thakral - Journal of pharmaceutical …, 2018 - Elsevier
Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry,
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …