Obesity and diabetes are the most demanding health problems today, and their prevalence,
as well as comorbidities, is on the rise all over the world. As time goes on, both are …

Medicinal plants have been used by mankind since ancient times, and many bioactive plant
secondary metabolites are applied nowadays both directly as drugs, and as raw materials …

Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

Virtual screening of phytochemicals was performed through molecular docking, simulations,
in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the …

Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer
pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its …

Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

Owing to the high diversity of terrestrial and marine organisms, natural products (secondary
metabolites) are some of the most successful source of drug leads for the treatment of many …

Abstract Background Acetylcholinesterase (AChE), a serine hydrolase, is primarily
responsible for the termination of signal transmission in the cholinergic system, owing to its …