Plants in anticancer drug discovery: from molecular mechanism to chemoprevention

AJ Siddiqui, S Jahan, R Singh, J Saxena… - BioMed Research …, 2022 - Wiley Online Library
Cancer is one of the primary causes of mortality globally, and the discovery of new
anticancer drugs is the most important need in recent times. Natural products have been …

Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs

K Zhai, A Mazurakova, L Koklesova, P Kubatka… - Biomolecules, 2021 - mdpi.com
Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological
properties, including anti-cancer activities. These natural compounds have potential utility in …

Is autophagy always a barrier to cisplatin therapy?

J Xu, DA Gewirtz - Biomolecules, 2022 - mdpi.com
Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review

W Zhang, F Zhang, Q Hu, X Xiao, L Ou, Y Chen, S Luo… - Chinese Medicine, 2021 - Springer
With the advanced discoveries in the field of pathogenesis, a series of cerebral diseases,
such as cerebral ischaemia, Alzheimer's disease, and depression, have been found to have …

Use of supercritical CO2 to obtain Baccharis uncinella extracts with antioxidant and antitumor activity

AM Lucas, AFML Bento, RMF Vargas, TB Scheffel… - Journal of CO2 …, 2021 - Elsevier
The aim of the present study is to evaluate the antioxidant activity (AA) of different fractions of
the supercritical extract of Baccharis uncinella, in addition to investigating and relating AA to …

Transcription factor ELK3 promotes stemness and oxaliplatin resistance of glioma cells by regulating RNASEH2A

Y Mei, D Chen, S He, J Ye, M Luo… - Hormone and …, 2023 - thieme-connect.com
Oxaliplatin is a member of the platinum group that is often used to treat glioma, a common
type of malignant brain tumor, though it does not come with desirable and notable effects …

LINC00470 represses cell autophagy and cisplatin sensitivity of glioma via suppressing PTEN expression

B Chen, W Wang, F Lin, S Shi, S Ou, Y Yu - Folia Neuropathologica, 2023 - termedia.pl
Results: Through the above steps, we found that LINC00470 was highly expressed in
glioma cells, and the survival rate of patients was reduced in the presence of high …

[PDF][PDF] A Study on the Antioxidant and Active Compounds of Gardenia jasminoides Ellis (GJE) Leaves Extract.

I Yoga, DN Suprapta, IM Jawi… - Journal of Agricultural …, 2022 - account.jas.sljol.info
Purpose: The aim of this study was to isolate and identify the active compound antioxidant
fractions from Gardenia jasminoides Ellis leaves. Research Method: The antioxidant activity …

MicroRNA-485-5p inhibits glioblastoma progression by suppressing E2F transcription factor 1 under cisplatin treatment

C Huang, L Ma, F Duan, R Li, Y Zhang, Y Wang… - …, 2021 - Taylor & Francis
Cisplatin (CDDP) has been widely used for glioblastoma treatment. miR-485-5p and E2F
transcription factor 1 (E2F1) dysfunction has been reported in glioblastoma. Nonetheless …

[PDF][PDF] Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs. Biomolecules 2021, 11, 1841

K Zhai, A Mazurakova, L Koklesova, P Kubatka… - 2021 - academia.edu
Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological
properties, including anti-cancer activities. These natural compounds have potential utility in …