CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …

Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Sterol regulatory element-binding proteins (SREBPs) are a subfamily of basic helix–loop–
helix leucine zipper (bHLH-LZ) transcription factors that are conserved from fungi to humans …

Over the last 3 decades, the frequency of life-threatening human fungal infections has
increased as advances in medical therapies, solid-organ and hematopoietic stem cell …

Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol
biosynthesis, although the cellular basis for their antifungal activity is not understood. We …

Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …

Proteolytic enzymes play essential metabolic and regulatory functions in many biological
processes and also offer a wide range of biotechnological applications. Because of their …

Sterol regulatory element binding proteins (SREBPs) are a class of basic helix-loop-helix
transcription factors that regulate diverse cellular responses in eukaryotes. Adding to the …

Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription
factors whose proteolytic activation is controlled by the cellular sterol concentration …

Invasive fungal infections (IFIs) pose a serious clinical problem, but the antifungal arsenal is
limited and has many disadvantages, such as drug resistance and toxicity. Hence, there is …