[HTML][HTML] Malaria chemoprevention and drug resistance: a review of the literature and policy implications

CV Plowe - Malaria Journal, 2022 - Springer
Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria

RL Clark - Birth Defects Research, 2019 - Wiley Online Library
Malaria during pregnancy results in intrauterine growth restriction, fetal anemia, and infant
mortality. Women are more susceptible to malaria during pregnancy due to malaria‐induced …

Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

M Okada, P Guo, S Nalder, PA Sigala - Elife, 2020 - elifesciences.org
Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by
blocking protein translation in the essential apicoplast organelle. Clinical use is primarily …

[HTML][HTML] IFPTML mapping of drug graphs with protein and chromosome structural networks vs. Pre-clinical assay information for discovery of Antimalarial compounds

V Quevedo-Tumailli, B Ortega-Tenezaca… - International Journal of …, 2021 - mdpi.com
The parasite species of genus Plasmodium causes Malaria, which remains a major global
health problem due to parasite resistance to available Antimalarial drugs and increasing …

Safety of treating malaria with artemisinin-based combination therapy in the first trimester of pregnancy

RL Clark - Reproductive Toxicology, 2022 - Elsevier
There have been recent calls for the use of artemisinin-based combination therapies (ACTs)
for uncomplicated malaria in the first trimester of pregnancy. Nevertheless, the 2021 WHO …

Teratogen update: malaria in pregnancy and the use of antimalarial drugs in the first trimester

RL Clark - 2020 - Wiley Online Library
Malaria is a particular problem in pregnancy because of enhanced sensitivity, the possibility
of placental malaria, and adverse effects on pregnancy outcome. Artemisinin‐containing …

[HTML][HTML] Uptake of intermittent preventive treatment of malaria in pregnancy and risk factors for maternal anaemia and low birthweight among HIV-negative mothers in …

SLS Kamga, IM Ali, GR Ngangnang, MC Ulucesme… - Malaria Journal, 2024 - Springer
Background Approximately 32 million pregnant women are at risk of malaria with up to
10,000 maternal deaths and 200,000 neonates at risk annually. Intermittent Preventive …

Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action

EM Crisafulli, A De Paoli, MV Tutor, G Siddiqui… - BioRxiv, 2021 - biorxiv.org
Abstract The World Health Organisation (WHO) recommends artemisinin (ART)
combinations for treatment of uncomplicated Plasmodium falciparum malaria …

NIFPTML: aprendizaje automático por teoría de perturbaciones con fusión de información de redes biomoleculares en química médica, cromosómica, y …

VF Quevedo-Tumailli - 2022 - ruc.udc.es
La teoría de redes complejas permite estudiar sistemas biomoleculares. Dado que los
grafos pueden representar redes, en una red de proteína, como ejemplo, los nodos son los …

[HTML][HTML] Identifizierung neuer antiplasmodialer Wirkstoffe und Validierung von PfGSK3 als potentiellen Medikamentenangriffspunkt gegen Malaria

A Alder - 2020 - ediss.sub.uni-hamburg.de
Mit über 228 Mio. Infektionen im Jahr 2018, von denen ca. 405 000 tödlich verliefen, ist
Malaria eine der bedeutendsten Infektionskrankheiten der Welt. Verursacht wird die …