Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

This review summarizes the main achievements in basic and clinical research of
atherosclerosis. Focusing on desialylation as the first and the most important reaction of …

The functions of the influenza virus neuraminidase has been well documented but those of
the mammalian neuraminidases remain less explored. Here, we characterize the role of …

Sialic acids linked to glycoproteins and glycolipids are important mediators of cell and
protein recognition events. These sugar residues are removed by neuraminidases …

Abstract Sialidases (EC 3.2. 1.18, also called neuraminidases) catalyze the removal of α-
glycosidically linked sialic acid residues from glycoproteins and glycolipids; this is the initial …

Atherosclerosis manifests by the thickening of artery walls and their narrowed channels
through the accumulation of plaque. It is one of the most important indicators of …

Macrophages in atherosclerotic patients are notably plastic and heterogeneous. Single-cell
RNA sequencing (Sc RNA-seq) can provide information about all the RNAs in individual …

This Perspective describes the classification, structures, substrates, mechanisms of action,
and implications of human neuraminidases (hNEUs) in various pathologies. Some inhibitors …

The JAK)-STAT pathway is a crucial cellular signaling cascade, including an intricated
network of protein-protein interactions (PPIs) responsible of its regulation. It mediates the …

Apolipoproteins, the protein component of lipoproteins, play an important role in lipid
transport, lipoprotein assembly, and receptor recognition. Apolipoproteins are glycosylated …