Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale
spatial atlas of the healthy human body at single-cell resolution by applying advanced …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Only in recent years have we begun to appreciate the involvement of fibroblasts in intestinal
development, tissue homeostasis, and disease. These insights followed the advent of single …

Research on precancers, as defined as at-risk tissues and early lesions, is of high
significance given the effectiveness of early intervention. We discuss the need for risk …

Abstract Background Tertiary lymphoid structures (TLSs) are associated with a favorable
prognosis in several cancers. However, the correlation between TLSs and outcomes of …

Objective Biological insights into the stepwise development and progression of colorectal
cancer (CRC) are imperative to develop tailored approaches for early detection and optimal …

Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant
expansion of the normally restricted capability for cell state plasticity in neoplasia is poorly …

In recent years, research focused on the multifaceted landscape and functions of cancer-
associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities …