[HTML][HTML] The Jak/STAT pathway: A focus on pain in rheumatoid arthritis

LS Simon, PC Taylor, EH Choy, A Sebba… - Seminars in arthritis and …, 2021 - Elsevier
Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Difficult-to-treat rheumatoid arthritis: an area of unmet clinical need

MJH de Hair, JWG Jacobs, JLM Schoneveld… - …, 2018 - academic.oup.com
Increased effectiveness of pharmacological treatments in early RA has led many to believe
that difficult-to-treat, established RA is a condition of the past. However, there are still plenty …

Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study

B Michelsen, EK Kristianslund, J Sexton… - Annals of the …, 2017 - ard.bmj.com
Objective To investigate the predictive value of baseline depression/anxiety on the
likelihood of achieving joint remission in rheumatoid arthritis (RA) and psoriatic arthritis …

Mechanisms for joint pain in rheumatoid arthritis (RA): from cytokines to central sensitization

A Zhang, YC Lee - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review Pain in rheumatoid arthritis (RA) may be due to different
etiologies, ranging from peripheral inflammation to dysregulation of central nervous system …

Pain mechanism in rheumatoid arthritis: from cytokines to central sensitization

Y Cao, D Fan, Y Yin - Mediators of Inflammation, 2020 - Wiley Online Library
Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in
recent years, through the implementation of targeted treatment and the introduction of …

[HTML][HTML] Metabolomics in rheumatoid arthritis: Advances and review

L Xu, C Chang, P Jiang, K Wei, R Zhang, Y Jin… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations.
The metabolic profiles of patients with RA can be determined using targeted and non …

[HTML][HTML] Icariin-loaded hydrogel regulates bone marrow mesenchymal stem cell chondrogenic differentiation and promotes cartilage repair in osteoarthritis

Y Zhu, L Ye, X Cai, Z Li, Y Fan, F Yang - Frontiers in Bioengineering …, 2022 - frontiersin.org
Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for
cartilage protection and symptoms relief of osteoarthritis (OA). However, controlling …

The effect of physical exercise on rheumatoid arthritis: an overview of systematic reviews and meta‐analysis

H Hu, A Xu, C Gao, Z Wang… - Journal of advanced …, 2021 - Wiley Online Library
Aims To determine which outcomes will be improved by different exercise interventions and
the evidence quality for each intervention. Design Overview of systematic reviews and meta …

The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases

MA Guler, OF Celik, FF Ayhan - Clinical rheumatology, 2020 - Springer
Objective This study explored the role of central sensitization (CS) pain in patients with
various rheumatic diseases using the CS inventory (CSI). Methods A total of 193 patients of …

[HTML][HTML] Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent …

A Jurczak, L Delay, J Barbier, N Simon, E Krock… - Pain, 2022 - journals.lww.com
Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are
associated with a risk of developing persistent pain. Increased osteoclast activity is often the …