The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves
changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric …

GERD is a common condition worldwide. Key mechanisms of disease include abnormal
oesophagogastric junction structure and function, and impaired oesophageal clearance. A …

Best Practice Advice 1 A diagnosis of functional heartburn should be considered when
retrosternal burning pain or discomfort persists despite maximal (double-dose) proton pump …

Introduction Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic,
relapsing disorder, whose knowledge has increased in last years thanks to the advent of …

Introduction: Medical therapy of gastroesophageal reflux disease (GERD) is based on the
use of proton pump inhibitors (PPIs) as first choice treatment. Despite their effectiveness …

Background & Aims Wireless pH monitoring measures esophageal acid exposure time
(AET) for up to 96 hours. We evaluated competing methods of analysis of wireless pH data …

The definition of functional heartburn has been refined over the years. It is currently
described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of …

The Rome IV diagnostic criteria delineates 5 functional esophageal disorders which include
functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional …

Abstract Purpose of Review Proton pump inhibitor (PPI) use in gastroesophageal reflux
disease (GERD) has been redefined, in light of recent advances highlighting GERD …

Functional heartburn (FH) is defined as a functional esophageal disorder characterized by
symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In …