Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Background & Aims: The irritable bowel syndrome (IBS) is a common disorder characterized
by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Review Article Afferent and spinal mechanisms of joint pain Page 1 Pain, 55 (1993) 5-54 0
1993 Elsevier Science Publishers BV All rights reserved 0304-3959/93/$06.00 5 PAIN …

Recent findings suggest that the periaqueductal gray (PAG) can be subdivided on the basis
of its anatomical connections and functional representation of cardiovascular and behavioral …

Although physiological stimuli in the healthy gastrointestinal tract are generally not
associated with conscious perception, chronic abdominal discomfort and pain are the most …

Publisher Summary Considerable evidence suggests that the cell dense region surrounding
the midbrain aqueduct, the midbrain periaqueductal gray region (PAG), is a crucial neural …

It is well documented that the descending endogenous analgesia system, including the
periaqueductal gray (PAG) and the rostral ventral medulla (RVM), play an important role in …

Activation of neurons in the rostral ventral medulla, by electrical stimulation or microinjection
of glutamate, produces antinociception. Microinjection of opioid compounds in this region …