Cell signaling via inositol phosphates, in particular via the second messenger myo‐inositol
1, 4, 5‐trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine …

It is now slightly more than a decade since Michael Berridge and his collaborators reported
in Nature “… micromolar concentrations of Ins (1, 4, 5) P3 (1d‐myo‐inositol 1, 4, 5 …

DNA from bacteria has stimulatory effects on mammalian immune cells,,, which depend on
the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast …

Receptor-mediated generation of inositol 1, 4, 5-trisphosphate (InsP3) initiates Ca2+ release
from intracellular stores and the subsequent activation of store-operated calcium influx …

Inositol (1, 4, 5)-trisphosphate [Ins (1, 4, 5) P 3] originating in the vascular smooth-muscle
cells (VSMCs) has been shown to modulate the Ca2+ stores in endothelial cells (ECs) …

D-myo-Inositol 1, 4, 5-1risphosphate [Ins (1, 4.5) P3]-receptors are recognised as a
homologous family of tetrameric ligand-gated Ca2+ channels, which allow mobilisation of …

Zu einer Renaissance in der Inositphosphatchemie hat die Entdeckung der Rolle von myo‐
Inosit‐1, 4, 5‐trisphosphat 1 als sekundärer Botenstoff vor zwölf Jahren geführt: Es wurden …

Routes for the synthesis of racemic myo-inositol 1, 2, 4, 5-tetrakisphosphate DL-Ins (1, 2, 4,
5) P4 5ab and the chiral antipodes D-and L-myo-inositol 1, 2, 4, 5-tetrakisphosphate 5a and …

Novel benzene polyphosphates were synthesised as inositol polyphosphate mimics and
evaluated against type‐I inositol 1, 4, 5‐trisphosphate 5‐phosphatase, which only binds …

Abstract Various 2, 5‐and 1, 4‐substituted and unsubstituted myo‐inositol
tetrakisphosphates and bispyrophosphates were prepared following a general synthetic …