Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as
an important adverse pathological feature of many malignancies, including pancreatic …

Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately,
there is no targeted treatment for PNI since the molecular mechanisms are largely unknown …

Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …

Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

In the spinal nervous system, the expression of galanin (GAL) and galanin receptors
(GALRs) that play important roles in the transmission and modulation of nociceptive …

A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are
thought to contribute to the development and maintenance of neuropathic pain. However …

Increased patient survival is a mark of modern anti-cancer therapy success. Unfortunately
treatment side-effects such as neurotoxicity are a major long term concern. Sensory …

Chronic pain is highly comorbid with affective disorders, including major depressive
disorder. A core feature of major depressive disorder is a loss of interest in previously …

Diabetic peripheral neuropathic pain (DPNP) is a distal spontaneous pain, caused by lesion
of sensory neurons and accompanied by depression and anxiety frequently, which reduce …