Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Mitochondria are critical for regulation of the activation, differentiation, and survival of
macrophages and other immune cells. In response to various extracellular signals, such as …

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic
adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies …

Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in
interleukin-4 (IL-4)-mediated macrophage polarization (M (IL-4)). However, many of these …

A growing number of findings highlight the crucial role of metabolic reprogramming in
macrophage activation. Metabolic pathways are closely interconnected and recent literature …

Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages,
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …