Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future …
PY Wen, M Weller, EQ Lee, BM Alexander… - Neuro …, 2020 - academic.oup.com
Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …
cause of morbidity and mortality. In recent years there have been important advances in …
Inhibition and induction of CYP enzymes in humans: an update
The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …
Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial
PY Wen, A Stein, M van den Bent, J De Greve… - The lancet …, 2022 - thelancet.com
Background Effective treatments are needed to improve outcomes for high-grade glioma
and low-grade glioma. The activity and safety of dabrafenib plus trametinib were evaluated …
and low-grade glioma. The activity and safety of dabrafenib plus trametinib were evaluated …
Molecular targeted therapy of glioblastoma
E Le Rhun, M Preusser, P Roth, DA Reardon… - Cancer treatment …, 2019 - Elsevier
Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …
Recurrent glioblastoma: from molecular landscape to new treatment perspectives
Simple Summary Glioblastoma is the most common and aggressive malignant primary brain
cancer in adults. The prognosis remains poor following standard-of-care treatment with …
cancer in adults. The prognosis remains poor following standard-of-care treatment with …
Advances in the molecular genetics of gliomas—implications for classification and therapy
G Reifenberger, HG Wirsching… - Nature reviews Clinical …, 2017 - nature.com
Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …
alterations and epigenetic profiles associated with different types of gliomas. These …
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
Glioblastoma multiforme: Pathogenesis and treatment
C Alifieris, DT Trafalis - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Each year, about 5–6 cases out of 100,000 people are diagnosed with primary
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …
malignant brain tumors, of which about 80% are malignant gliomas (MGs). Glioblastoma …
[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …
representing a highly heterogeneous group of neoplasms that are among the most …
Current standards of care in glioblastoma therapy
C Fernandes, A Costa, L Osório, RC Lago… - Exon …, 2017 - exonpublications.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …