It is broadly accepted that genetically engineered animal models do not always recapitulate
human pathobiology. Therefore identifying best-fit mouse models of human cancers that …

Objectives: Since virus-related hepatocellular carcinoma (HCC) is quite complexed, the
etiology of virus-associated HCC is remained unclear. We have previously shown that the …

Sex/gender disparity has been shown in the incidence and prognosis of many types of
diseases, probably due to differences in genes, physiological conditions such as hormones …

Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of
the liver by initiating complex pathological events characterized by steatosis, steatohepatitis …

The constitutive androstane receptor (CAR) controls the expression of drug-metabolizing
enzymes and regulates hepatocyte proliferation. Studies with transgenic mice with an early …

La alteración de las vías de señalización es un mecanismo común en la oncogénesis de
diferentes tipos de tumor. La modificación de una de las proteínas de la vía por mutaciones …

In the present study, we investigated the antitumor activity of caudatin in the human
hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis …

The two microRNAs miR-192 and miR-194 are abundantly expressed in the liver and are
considered serum biomarkers of liver injury. However, their role in the development of liver …

Hepatic progenitor cells (HPCs) appear to play an important role in chronic liver injury. In
this study, cirrhosis was induced in F-344 rats (n= 32) via subcutaneous injection of 50 …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that are capable of
differentiate into multilineage cell types including bone in vitro and in vivo. Aim of the study …