During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic
status, presenting a heavy burden on society. It is therefore essential to find novel …

Insulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in
many cell types. The translocation of GLUT4 from intracellular membranes to the cell surface …

Fatty acids (FAs) rapidly and efficiently reduce cardiac glucose uptake in the Randle cycle or
glucose-FA cycle. This fine-tuned physiological regulation is critical to allow optimal …

Abstract It is estimated 6.4% of males and 1.6% of females globally use anabolic-androgenic
steroids (AAS), mostly for appearance and performance enhancing reasons. In combination …

In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on
chromosome 5. They share sequence homology, functions and associations with immune …

CD36 and GLUT4 are the main cardiac trans-sarcolemmal transporters for long-chain fatty
acids and glucose, respectively. Together they secure the majority of cardiac energy …

Abstract The Ser/Thr kinase protein kinase-D1 (PKD1) is involved in induction of various cell
physiological processes in the heart such as myocellular hypertrophy and inflammation …

Catestatin (CST) is a pleiotropic peptide with cardioprotective and metabolic effects. CST is
involved in the pathogenesis of both arterial hypertension (AH) and type 2 diabetes mellitus …