Glioblastoma is the most aggressive and the most common primary malignant brain tumor in
adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally …

Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a
poor prognosis and limited treatment options. Diagnosis is often challenging, with …

Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC)
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …

Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the
leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung …

Background: Diagnosis of leptomeningeal metastasis (LM) has become increasingly
frequent. The diagnostic gold standard has been CSF cytology, but MRI is now used …

Abstract Background The EANO ESMO guidelines have proposed a classification of
leptomeningeal metastases (LM) from solid cancers based on clinical, magnetic resonance …

The incidence of metastasis to the brain is apparently rising in cancer patients and threatens
to limit the gains that have been made by new systemic treatments. The brain is considered …

Leptomeningeal metastasis (LM), ie the seeding of tumor cells to the cerebrospinal fluid
(CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various …

Neoplastic meningitis is a complication of the CNS that occurs in 3–5% of patients with
cancer and is characterised by multifocal neurological signs and symptoms. Diagnosis is …

Background The incidence of leptomeningeal carcinomatosis (LC) has increased in patients
with metastatic non–small-cell lung cancer (NSCLC) because of recent improvements in …