Imaging and impact of myocardial fibrosis in aortic stenosis

R Bing, JL Cavalcante, RJ Everett, MA Clavel… - JACC: Cardiovascular …, 2019 - jacc.org
Aortic stenosis is characterized both by progressive valve narrowing and the left ventricular
remodeling response that ensues. The only effective treatment is aortic valve replacement …

Myocardial T1 and ECV measurement: underlying concepts and technical considerations

AA Robinson, K Chow, M Salerno - JACC: Cardiovascular Imaging, 2019 - jacc.org
Myocardial native T1 and extracellular volume fraction (ECV) mapping have emerged as
cardiac magnetic resonance biomarkers providing unique insight into cardiac …

Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta …

J Magne, B Cosyns, BA Popescu… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives: In this individual participant data meta-analysis on left ventricular global
longitudinal strain (LVGLS), our objective was to: 1) describe its distribution; 2) identify the …

Extracellular myocardial volume in patients with aortic stenosis

RJ Everett, TA Treibel, M Fukui, H Lee, M Rigolli… - Journal of the American …, 2020 - jacc.org
Background Myocardial fibrosis is a key mechanism of left ventricular decompensation in
aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) …

Reserve of right ventricular-arterial coupling in the setting of chronic overload

K Tello, A Dalmer, J Axmann, R Vanderpool… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: Right ventricular (RV) maladaptation and failure determine outcome in
pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial …

Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of …

M Puls, BE Beuthner, R Topci… - European heart …, 2020 - academic.oup.com
Aims Myocardial fibrosis (MF) might represent a key player in pathophysiology of heart
failure in aortic stenosis (AS). We aimed to assess its impact on left ventricular (LV) …

Emerging molecular imaging targets and tools for myocardial fibrosis detection

AK Barton, E Tzolos, R Bing, T Singh… - European Heart …, 2023 - academic.oup.com
Myocardial fibrosis is the heart's common healing response to injury. While initially seeking
to optimize the strength of diseased tissue, fibrosis can become maladaptive, producing stiff …

Markers of myocardial damage predict mortality in patients with aortic stenosis

S Kwak, RJ Everett, TA Treibel, S Yang… - Journal of the American …, 2021 - jacc.org
Background Cardiovascular magnetic resonance (CMR) is increasingly used for risk
stratification in aortic stenosis (AS). However, the relative prognostic power of CMR markers …

Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis

L Tastet, J Kwiecinski, P Pibarot, R Capoulade… - Cardiovascular …, 2020 - jacc.org
Objectives The aim of this study was to assess the effect of sex on myocardial fibrosis as
assessed by using cardiac magnetic resonance (CMR) imaging in aortic stenosis (AS) …

Myocardial fibrosis: why image, how to image and clinical implications

R Bing, MR Dweck - Heart, 2019 - heart.bmj.com
The current era has seen major advances in myocardial imaging. We are now able to
assess cardiac anatomy, function, tissue composition and disease activity across a wide …