Non-alcoholic steatohepatitis (NASH) can cause liver cirrhosis and hepatocellular
carcinoma (HCC), with cases increasing worldwide. To reduce the incidence of liver …

Gap junction channels (GJCs) mediate intercellular communication and are gated by
numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 …

Diffusion through semipermeable interfaces has a wide range of applications, ranging from
molecular transport through biological membranes to reverse osmosis for water purification …

Neuronal activity must be tightly coordinated with blood flow to keep proper brain function,
which is achieved by a mechanism known as neurovascular coupling. Then, an increase in …

Abstract Connexin26 (Cx26) and Cx30 are predominant isoforms of gap junction channels
in the cochlea and play a critical role in hearing. In this study, the cellular distributions of …

Hanahan and Weinberg (2000, Cell 100: 57‐70) listed “hallmarks” of cancer that must be
considered in order to understand the underlying determinants of carcinogenesis:(a) self …

The mechanisms that determine whether neural stem cells remain in a proliferative state or
differentiate into neurons or glia are largely unknown. Here we establish a pivotal role for …

Targeted delivery of therapeutics through the use of nanoparticles (NPs) has emerged as a
promising method that increases their efficacy and reduces their side effects. NPs can be …

Glycyrrhetinic acid (GA) and its related compounds are known to have anti-inflammatory
activity and also to inhibit liver carcinogenesis and tumor growth. GA and related …

Glial dysfunction is a major pathophysiological feature of mood disorders. While altered
astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with …