[HTML][HTML] Risk factors for the development of psoriasis

K Kamiya, M Kishimoto, J Sugai, M Komine… - International journal of …, 2019 - mdpi.com
Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms
involve complex interaction between the innate and adaptive immune system. T cells …

[HTML][HTML] Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases

K Bunte, T Beikler - International journal of molecular sciences, 2019 - mdpi.com
Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …

[HTML][HTML] TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

C Conrad, J Di Domizio, A Mylonas… - Nature …, 2018 - nature.com
Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of
psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical …

Drug-induced psoriasis: clinical perspectives

DMW Balak, E Hajdarbegovic - Psoriasis: Targets and Therapy, 2017 - Taylor & Francis
Exposure to certain drugs can elicit an induction or exacerbation of psoriasis. Although well-
conducted systematic studies on drug-related psoriasis are mostly lacking, traditionally …

Paradoxical eruptions to targeted therapies in dermatology: a systematic review and analysis

MJ Murphy, JM Cohen, MD Vesely… - Journal of the American …, 2022 - Elsevier
Background Antibody-based therapies that inhibit proinflammatory cytokine signaling are
commonly used in dermatology. Paradoxically, these medications may induce or exacerbate …

[HTML][HTML] Psoriasis: classical vs. paradoxical. The Yin-Yang of TNF and type I interferon

A Mylonas, C Conrad - Frontiers in immunology, 2018 - frontiersin.org
Chronic plaque psoriasis is a common debilitating skin disease. The identification of the
pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted …

[HTML][HTML] Psoriasis and antimicrobial peptides

T Takahashi, K Yamasaki - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells
such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) …

TNF inhibitor-induced psoriasis: proposed algorithm for treatment and management

SJ Li, LM Perez-Chada… - Journal of psoriasis and …, 2019 - journals.sagepub.com
Tumor necrosis factor α (TNF-α)-targeted therapies have expanded the therapeutic options
for patients with inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis, and …

[PDF][PDF] Psoriasis risk factors and triggers

EB Lee, KK Wu, MP Lee, T Bhutani, JJ Wu - Cutis, 2018 - cdn.mdedge.com
VOL. 102 NO. 5S I NOVEMBER 2018 19 WWW. MDEDGE. COM/CUTIS is caspase
recruitment domain family member 14, CARD14 (formerly PSORS2), a gene encoding a …

Tumor necrosis factor-α inhibitor-related autoimmune disorders

L De Stefano, FB Pallavicini, E Mauric, V Piccin… - Autoimmunity …, 2023 - Elsevier
Biotechnological monoclonal antibodies and receptor antagonists capable of targeting
specific inflammatory actors, such as cytokines, cytokines receptors, co-stimulatory …