Microglia, the resident CNS macrophages, have been implicated in the pathogenesis of Rett
Syndrome (RTT), an X-linked neurodevelopmental disorder. However, the mechanism by …

The immune response after brain injury is highly complex and involves both local and
systemic events at the cellular and molecular level. It is associated to a dramatic over …

Neuropsychiatric lupus (NPSLE) is a frequent manifestation of systemic lupus
erythematosus (SLE) that occurs in 40–90% of SLE patients; however, the underlying …

Complement is recognized as a key player in a wide range of normal as well as disease-
related immune, developmental and homeostatic processes. Knowledge of complement …

Microglia, the resident macrophage cells of the central nervous system (CNS), are involved
in a myriad of processes required to maintain CNS homeostasis. These cells are dynamic …

Aging is associated with gradual deterioration of physiological and biochemical functions,
including cognitive decline. Transcriptome profiling of brain samples from individuals of …

Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …

The pathogenesis of schizophrenia is considered to be multi-factorial, with likely gene–
environment interactions (GEI). Genetic and environmental risk factors are being identified …

In the central nervous system, synaptic pruning, the removal of unnecessary synaptic
contacts, is an essential process for proper circuit maturation in neurodevelopment as well …

The complement system, an effector arm of the innate immune system that plays a critical
role in tissue inflammation, the elimination of pathogens and the clearance of dead cells and …