The fragmentation pathways of protonated peptides are reviewed in the present paper
paying special attention to classification of the known fragmentation channels into a simple …

Protein identification and peptide sequencing by tandem mass spectrometry requires
knowledge of how peptides fragment in the gas phase, specifically which bonds are broken …

The most commonly used activation method in the tandem mass spectrometry (MS) of
peptides and proteins is energetic collisions with a neutral target gas. The overall process of …

Abstract I. Introduction 58 A. Challenges in the Gas‐Phase Fragmentation of Polypeptides
58 B. Ion–Electron Interactions 58 C. Nomenclature 59 II. Instrumental Realization and …

A kinetic model, based on the “mobile proton” model of peptide fragmentation, was
developed to quantitatively simulate the low-energy collision-induced dissociation (CID) …

Collision-induced dissociation (CID) is a common ion activation technique used to energize
mass-selected peptide ions during tandem mass spectrometry. Characteristic fragment ions …

Abstract I. Introduction 87 II. Discussion 88 A. The Backbone Cleavages of (M‐H)− Parent
Anions of Peptides 88 1. α‐and β‐Backbone Cleavages 89 2. The β′ Cleavage 92 3. The …

The gas-phase structures of the protonated pentapeptide Leu-enkephalin and its main
collision-induced dissociation (CID) product ions, b 4 and a 4, are investigated by means of …

The primary utility of trypsin digestion in proteomics is that it cleaves proteins at predictable
locations, but it is also notable for yielding peptides that terminate in basic arginine and …

One of the major factors governing the “top-down” sequence analysis of intact multiply
protonated proteins by tandem mass spectrometry is the effect of the precursor ion charge …