Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Globally, gastrointestinal cancers represent more than one-fourth of all cancer incidence
and one-third of cancer-related mortality. Although there has been much progress in …

Importance Emerging data suggest that the incidence of early-onset cancers, defined as
cancers diagnosed in people younger than 50 years, is increasing, but updated data are …

Background & Aims Despite the widespread increase in the incidence of early-onset
colorectal cancer (EoCRC), the reasons for this increase remain unclear. The objective of …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Objective Sugar-sweetened beverage (SSB) consumption had substantially increased
across successive US birth cohorts until 2000, and adolescents and young adults under age …

Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing.
Here, we aimed to characterise the interactions between gut microbiome, metabolites and …