Retinal pigment epithelium (RPE) is a monolayer of cuboidal cells that is strategically placed
between the rod and cone photoreceptors and the vascular bed of the choriocapillaris. It has …

The research that led to the concept of using prostaglandins for reduction of intraocular
pressure (IOP) has been discussed by Bito and goes back to the early 1980s, when it was …

In the last decade topically applied prostaglandin F2α analogues (bimatoprost, latanoprost,
travoprost and unoprostone) have become widely used as a means to reduce elevated …

To evaluate the pharmacological characteristics of AFP-168 (tafluprost), a new
prostaglandin (PG) F2α derivative, we examined its receptor-binding affinities, intraocular …

Glaucoma affects millions of people around the world. With the baby boom generation
aging, the number of people affected by primary open-angle glaucoma in the US is expected …

The new glaucoma drugs latanoprost, isopropyl unoprostone, travoprost, and bimatoprost
cause increased pigmentation of the iris in some patients. The purpose of the present article …

Objective To evaluate the 5-year safety and efficacy of adjunctive 0.005% latanoprostonce
daily. Methods Patients with primary open-angle or exfoliation glaucoma who completeda 3 …

MATERIALS AND METHODS Materials Prostarumon® F injection 1000 (1mg/ml PGF2a)
was obtained from Ono Pharmaceutical Co., Ltd.(Osaka, Japan), while cloprostenol was …

Prostaglandin (PG) analogues are a new class of ocular hypotensive drugs that have been
developed for the treatment of open angle glaucoma. Two of these drugs, latanoprost and …

Purpose To evaluate the ocular factors contributing to keratoepitheliopathy in glaucoma
patients treated with or without anti-glaucomatous eyedrops, and the influences of each anti …