In this study, the concept of dynamic combinatorial chemistry (DCC) was applied to explore
novel cholesterol esterase (CEase) inhibitors. In the presence of enzyme, two substrates …

A series of phosphorylated flavonoids were synthesized and investigated in vitro as
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …

Abstract A library of forty 7, 8-benzoflavone derivatives was synthesized and evaluated for
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …

There are three major active sites of butyrylcholinesterase: catalytic site, peripheral site, and
activator site. In this study, pseudosubstrate inhibitors, 1, 3, 5-alkylcarbamyloxybenzenes (1 …

Abstract A series of 2-(substituted) phenyl and 2-indolyl quinoline derivatives (10a–l) was
synthesized by an efficient microwave-assisted, trifluoroacetic acid-catalyzed, solvent-free …

Cancer is a serious health concern growing at a rapid speed where normal cells take
neoplastic transformation. Different pathway is tightly regulated with each other to maintain …

Cholesterol esterase (CEase), a serine hydrolase thought to be involved in atherogenesis
and thus coronary heart disease, is considered as a target for inhibitor development. We …

Abstract A library of 3, 4, 6, 7-tetrahydro-3, 3, 6, 6-tetramethyl-9, 10-diphenylacridine-1, 8-
dione derivatives were synthesized via microwave-assisted three-component reaction …

In a continued effort to develop potent cholesterol esterase (CEase) inhibitors, a series of 5,
6-benzoflavone derivatives was rationally designed and synthesized by changing the …

No presente trabalho sintetizou-se ésteres graxos derivados de ácidos graxos naturais e
fenóis com o objetivo de se obter novos tensoativos biodegradáveis e biocompatíveis. A …