In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …

The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-
microbiota-derived signals supports the maintenance of tolerance. However, whether …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes,
into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Secondary lymphoid tissues share the important function of bringing together antigens and
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …