Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection
of variants with improved affinity for antigen. Long-lived memory B cells and plasma cells are …

The development of high-affinity B cell memory is regulated through three separable
phases, each involving antigen recognition by specific B cells and cognate T helper cells …

We identify the interfollicular (IF) zone as the site where germinal center B cell and T
follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization …

Epstein–Barr virus-induced gene 2 (EBI2, also known as GPR183) is a G-protein-coupled
receptor that is required for humoral immune responses; polymorphisms in the receptor …

Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …

Both preclinical and established rheumatoid arthritis (RA) patients display alterations in the
gut microbiome. Prevotella spp. are preferentially enriched in a subset of RA patients. Here …

The transcription factor Bcl6 is essential for the development of germinal center (GC) B cells
and follicular helper T (Tfh) cells. However, little is known about in vivo dynamics of Bcl6 …

Follicular helper T cells (Tfh cells) are required for T cell help to B cells, and BCL6 is the
defining transcription factor of Tfh cells. However, the functions of BCL6 in Tfh cells have …

Follicular helper T (TFH) cells are essential for B-cell maturation and immunoglobulin
production after immunization with thymus-dependent antigens. Nevertheless, the …