This paper synthesizes recent progress toward understanding the integrated control systems
and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus …

The best-understood mechanisms for achieving antibody self/non-self discrimination discard
self-reactive antibodies before they can be tested for binding microbial antigens, potentially …

In germinal centres, somatic hypermutation and B cell selection increase antibody affinity
and specificity for the immunizing antigen, but the generation of autoreactive B cells is an …

Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …

Abstract EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly
expressed in spleen and upregulated upon Epstein–Barr-virus infection. Recent studies …

Intermediates in the cholesterol-biosynthetic pathway and oxysterol derivatives of
cholesterol regulate diverse cellular processes. Recent studies have expanded the …

Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue
integrity in the intestine. Yet, which signals are sensed and what receptors control ILC3 …

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of
migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of …

Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …

Germinal centers (GCs) support high-affinity, long-lived humoral immunity. How memory B
cells develop in GCs is not clear. Through the use of a cell-cycle-reporting system, we …