Abstract EBV-induced gene 2 (EBI2) was recently shown to direct the delayed movement of
activated B cells to interfollicular and outer follicular regions of secondary lymphoid organs …

One mechanism by which disease-associated DNA variation can alter disease risk is
altering gene expression. However, linkage disequilibrium (LD) between variants, mostly …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects the joints. Self-reactive B and T lymphocytes cooperate to promote antibody …

Mature B cell differentiation involves a well-established transcription factor cascade.
However, the temporal dynamics of cell signaling pathways regulating transcription factor …

INTRODUCTION Development of long-term antibody-mediated immunity relies on the
germinal center (GC) reaction, in which CD4+ T cells help B cells to proliferate and …

During viral infection, immune cells coordinate the induction of inflammatory responses that
clear infection and humoral responses that promote protection. CD4+ T-cell differentiation …

Interactions between B‐cell antigen receptors (BCRs) and their ligands have a complexity
and variability that is unparalleled within known biology. Each developing B cell undergoes …

Germinal centers (GCs) are sites of rapid B‐cell proliferation and somatic mutation. These
ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell …

Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular regions
of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive …

Oxysterols are cholesterol metabolites now considered bona fide bioactive lipids. Recent
studies have identified new receptors for oxysterols involved in immune and inflammatory …