It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B
cells influence the unfolding differentiation before germinal center (GC) formation. By …

Infection with helminths and exposure to antigens induce a strong type 2 immune response
resulting in the secretion of the cytokines IL‐4 and IL‐13 by CD 4+ T cells and several innate …

Background We previously reported that reduced GPR183 expression in blood from
tuberculosis (TB) patients with diabetes is associated with more severe TB. Methods To …

The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a
risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α, 25 …

The development of chronic obstructive pulmonary disease (COPD) pathogenesis remains
unclear, but emerging evidence supports a crucial role for inducible bronchus‐associated …

Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory
bowel disease (IBD). The oxysterol receptor GPR183 and its ligands, dihydroxylated …

Background B cells play many roles in health and disease. However, little is known about
the mechanisms that drive B cell responses in the airways, especially in humans. Chronic …

Antibody affinity maturation occurs in the germinal center (GC), a highly dynamic structure
that arises upon antigen stimulation and recedes after infection is resolved. While the …

During antibody responses, B cells undergo a series of migratory events that guide them to
the appropriate microenvironments for activation and differentiation. Epstein–Barr virus …

Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions
produce high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary …