Crowded charges in ion channels

B Eisenberg - Advances in chemical physics, 2011 - Wiley Online Library
Ions in water are the liquid of life. Life occurs almost entirely in “salt water.” Life began in
salty oceans. Animals kept that salt water within them when they moved out of the ocean to …

Susceptibility genes and modifiers for cardiac arrhythmias

S Kääb, E Schulze-Bahr - Cardiovascular research, 2005 - academic.oup.com
The last decade has seen a dramatic increase in the understanding of the molecular basis of
arrhythmias. Much of this new information has been driven by genetic studies that focused …

Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype

DS Souza, LP Marques, AD Costa, JS Cruz, P Rhana… - Life Sciences, 2022 - Elsevier
Aims Hypothyroidism is associated with an increased risk of cardiovascular disease and
enhanced susceptibility to arrhythmias. In our investigation, we evaluated the potential …

Polymorphic ventricular tachycardia and KCNJ2 mutations

TUH Chun, MR Epstein, M Dick II, G Andelfinger… - Heart Rhythm, 2004 - Elsevier
We sought to identify the electrophysiologic basis of life-threatening events associated with
polymorphic ventricular tachycardia (PVT) in young patients with heterozygous KCNJ2 …

Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes

Z Sun, PM Milos, JF Thompson, DB Lloyd… - Journal of molecular and …, 2004 - Elsevier
Various drugs are reported to prolong the QT-interval on the surface ECG, thereby
increasing the risk of developing a potentially fatal arrhythmia known as Torsades de …

Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome

CW Lu, JH Lin, YS Rajawat, H Jerng… - Journal of medical …, 2006 - jmg.bmj.com
Background: Andersen-Tawil syndrome (ATS) is a rare inherited disorder, characterised by
periodic paralysis, cardiac dysarrhythmias, and dysmorphic features, and is caused by …

[HTML][HTML] Bidirectional ventricular tachycardia with myocardial infarction: a case report with insight on mechanism and treatment

A Wase, AM Masood, NV Garikipati, O Mufti, A Kabir - indian heart journal, 2014 - Elsevier
Bidirectional ventricular tachycardia (BVT) is a rare variety of tachycardia with
morphologically distinct presentation: The QRS axis and/or morphology is alternating in the …

Long QT syndrome in South Africa: the results of comprehensive genetic screening: cardiovascular topic

PL Hedley, GA Durrheim, F Hendricks… - … journal of Africa, 2013 - journals.co.za
Congenital long QT syndrome (cLQTS) is a genetic disorder predisposing to ventricular
arrhythmia, syncope and sudden death. Over 700 different cLQTS-causing mutations in 13 …

Bidirectional ventricular tachycardia due to coronary allograft vasculopathy a unique presentation

SP Bhavnani, CA Clyne - Annals of Noninvasive …, 2012 - Wiley Online Library
Bidirectional ventricular tachycardia (BVT) is an uncommon type of polymorphic ventricular
tachycardia (PVT) with alternating polarity of the QRS complex most commonly described …