[HTML][HTML] Adipokines as clinically relevant therapeutic targets in obesity

M Würfel, M Blüher, M Stumvoll, T Ebert, P Kovacs… - Biomedicines, 2023 - mdpi.com
Adipokines provide an outstanding role in the comprehensive etiology of obesity and may
link adipose tissue dysfunction to further metabolic and cardiovascular complications …

[HTML][HTML] The role of selected adipocytokines in ovarian cancer and endometrial cancer

S Stępień, P Olczyk, J Gola, K Komosińska-Vassev… - Cells, 2023 - mdpi.com
Due to their multidirectional influence, adipocytokines are currently the subject of numerous
intensive studies. Significant impact applies to many processes, both physiological and …

[HTML][HTML] The role of chemerin in metabolic and cardiovascular disease: a literature review of its physiology and pathology from a nutritional perspective

L Tan, X Lu, AHJ Danser, K Verdonk - Nutrients, 2023 - mdpi.com
Chemerin is a novel adipokine that plays a major role in adipogenesis and lipid metabolism.
It also induces inflammation and affects insulin signaling, steroidogenesis and …

[HTML][HTML] Chemerin forms: their generation and activity

L Zhao, LL Leung, J Morser - Biomedicines, 2022 - mdpi.com
Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143
amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic …

[HTML][HTML] Molecular pharmacology of inflammation resolution in atherosclerosis

S Kotlyarov, A Kotlyarova - International Journal of Molecular Sciences, 2022 - mdpi.com
Atherosclerosis is one of the most important problems of modern medicine as it is the
leading cause of hospitalizations, disability, and mortality. The key role in the development …

[HTML][HTML] Understanding the role of chemerin in the pathophysiology of pre-eclampsia

K Pankiewicz, T Issat - Antioxidants, 2023 - mdpi.com
Chemerin is a multifaceted adipokine that is involved in multiple biological processes,
including inflammation, angiogenesis, adipogenesis, and energy metabolism, as well as …

[HTML][HTML] Role of chemerin in cardiovascular diseases

MT Macvanin, M Rizzo, J Radovanovic, A Sonmez… - Biomedicines, 2022 - mdpi.com
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …

Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin

AWC Man, Y Zhou, G Reifenberg, A Camp… - Cardiovascular …, 2023 - academic.oup.com
Aims Obesity is an epidemic that is a critical contributor to hypertension and other
cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase …

[HTML][HTML] The regulatory roles of chemerin-chemokine-like receptor 1 axis in placental development and vascular remodeling during early pregnancy

Q Zhang, Z Xiao, CL Lee, YG Duan, X Fan… - Frontiers in Cell and …, 2022 - frontiersin.org
Chemerin is an adipokine that regulates metabolism in pregnancy. An elevation of serum
chemerin level is associated with pregnancy complications. Consistently, we demonstrated …

[HTML][HTML] Structural basis of G protein–Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist

X Zhang, T Weiß, MH Cheng, S Chen… - PLoS …, 2023 - journals.plos.org
Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) or
chemerin receptor 1, is a chemoattractant G protein–coupled receptor (GPCR) that responds …