The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

Abstract Classical psychedelics with 5-hydroxytryptamine-2A receptor (5-HT 2A R) agonism
have rapid antidepressant actions in patients with depression. However, there is an ongoing …

Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine,
an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model …

Patients with depression exhibit reduced bone mineral density (BMD). We previously
reported that the new antidepressant arketamine improved the reduced BMD seen in …

Anesthetic ketamine and classical psychedelics that act as 5-hydroxytryptamine-2A receptor
(5-HT 2A R) agonists demonstrated rapid and sustained antidepressant actions in patients …

Depression is a frequent symptom in patients with chronic liver disease; however, the
mechanisms underlying this association remain unclear. Dysbiosis of gut microbiota plays a …

The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …

Emergence delirium (ED) is a common mental complication during recovery from
anesthesia. However, studies on the effects of esketamine, an intravenous anesthetic for …

Background Depression is a prevalent mood disorder during the perioperative period, with
both preoperative concurrent depression and new-onset postoperative depression …