Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
Linking long noncoding RNA localization and function
LL Chen - Trends in biochemical sciences, 2016 - cell.com
Recent studies have revealed the regulatory potential of many long noncoding RNAs
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
Regulation by 3′-untranslated regions
C Mayr - Annual review of genetics, 2017 - annualreviews.org
3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
RNA‐Seq methods for transcriptome analysis
R Hrdlickova, M Toloue, B Tian - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Deep sequencing has been revolutionizing biology and medicine in recent years, providing
single base‐level precision for our understanding of nucleic acid sequences in high …
single base‐level precision for our understanding of nucleic acid sequences in high …
Nascent RNA analyses: tracking transcription and its regulation
The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …
genome. Decoding of this information begins with regulated transcription of genomic DNA …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
[HTML][HTML] Translation affects mRNA stability in a codon-dependent manner in human cells
mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …
also been shown to affect mRNA stability depending on codon composition in model …
[HTML][HTML] ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
E Sundaramoorthy, M Leonard, R Mak, J Liao… - Molecular cell, 2017 - cell.com
Ribosomes that experience terminal stalls during translation are resolved by ribosome-
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …
Evolution and biological roles of alternative 3′ UTRs
C Mayr - Trends in cell biology, 2016 - cell.com
More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression
More than half of human genes use alternative cleavage and polyadenylation (ApA) to
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …