Proteomes are complex—much more so than genomes or transcriptomes. Thus, simplifying
their analysis does not simplify the issue. Proteomes are of proteoforms, not canonical …

Abstract Two-dimensional gel electrophoresis (2-DE) is a technique that has been widely
applied in a variety of proteomics studies. It is capable of resolving complex protein mixtures …

Two-dimensional gel electrophoresis (2DE) is an important and well-established technical
platform enabling extensive top-down proteomic analysis. However, the long-held but now …

Protein phosphorylation is a reversible post-translational modification (PTM) with major
regulatory roles in many cellular processes. However, the analysis of phosphoproteins …

The main intricacy in the human proteome is that it is tremendously complex and composed
from diverse and heterogeneous gene products. These products are called protein species …

Introduction: Tumor-associated proteins released by cancer cells and by tumor stroma cells,
referred as 'cancer secretome', represent a valuable resource for discovery of potential …

The burden of colorectal cancer (CRC) is considerable—approximately 1.8 million people
are diagnosed each year with CRC and of these about half will succumb to the disease. In …

With growing recognition and acknowledgement of the genuine complexity of proteomes, we
are finally entering the post-proteogenomic era. Routine assessment of proteomes as …

Studies of phage capsids have at least three potential interfaces with nanomedicine. First,
investigation of phage capsid states potentially will provide therapies targeted to similar …

We have previously developed an approach, where two-dimensional gel electrophoresis
(2DE) was used, followed by sectional analysis of the whole gel using high-resolution nano …