Synucleinopathy in amyotrophic lateral sclerosis: a potential avenue for antisense therapeutics?
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
classified as both a neurodegenerative and neuromuscular disorder. With a complex …
classified as both a neurodegenerative and neuromuscular disorder. With a complex …
ATP13A2 (PARK9) and basal ganglia function
KM Croucher, SM Fleming - Frontiers in Neurology, 2024 - frontiersin.org
ATP13A2 is a lysosomal protein involved in polyamine transport with loss of function
mutations associated with multiple neurodegenerative conditions. These include early onset …
mutations associated with multiple neurodegenerative conditions. These include early onset …
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin and kynurenine induce Parkin expression in neuroblastoma cells through different signaling pathways mediated by the aryl …
FE Murillo-González, R García-Aguilar… - Toxicology Letters, 2024 - Elsevier
Parkin regulates protein degradation and mitophagy in dopaminergic neurons. Deficiencies
in Parkin expression or function lead to cellular stress, cell degeneration, and the death of …
in Parkin expression or function lead to cellular stress, cell degeneration, and the death of …
Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders
S Vrijsen, RA El Asrar, MC Houdou, C Van den Haute… - bioRxiv, 2023 - biorxiv.org
ATP13A2 is a late endolysosomal transporter that exports the polyamines spermine and
spermidine from the organellar lumen to the cytosol. Loss-of-function variants in ATP13A2 …
spermidine from the organellar lumen to the cytosol. Loss-of-function variants in ATP13A2 …
[PDF][PDF] Caracterización molecular de la expresión del gen de Parkina (PRKN) mediada por el AHR en células de neuroblastoma humano
FE Murillo González - 2024 - repositorio.cinvestav.mx
La Parkina es una enzima E3 ligasa que regula la degradación de proteínas y la mitofagia
en neuronas dopaminérgicas. Las deficiencias en su expresión o función resultan en estrés …
en neuronas dopaminérgicas. Las deficiencias en su expresión o función resultan en estrés …
Current understanding of the association between Amyotrophic lateral sclerosis and frontotemporal dementia: Letter to Editor
J Zhang, H Wang - Neurology Letters, 2023 - neurologyletters.com
Neurology Letters│ www. neurologyle ers. com with both diseases. The most common
genetic mutation associated with ALS is C9ORF72, which is also associated with FTD. In …
genetic mutation associated with ALS is C9ORF72, which is also associated with FTD. In …