Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Patients with acute liver failure (ALF) have systemic innate immune suppression and
increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by …

Biomarkers have been used in sepsis to assist with the diagnosis of disease as well as
determining the severity of disease, that is, prognosis. These biomarkers are based on the …

Background Late mortality risk in sepsis-survivors persists for years with high readmission
rates and low quality of life. The present study seeks to link the clinical sepsis-survivors …

Increased epithelial permeability in sepsis is mediated via disruptions in tight junctions,
which are closely associated with the perijunctional actin-myosin ring. Genetic deletion of …

The acute respiratory distress syndrome (ARDS) describes a heterogenous population of
patients with acute severe respiratory failure. However, contemporary advances have begun …

Background Subphenotypes were recently reported within clinical acute respiratory distress
syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models …

Background: Sepsis is associated with high rates of in-hospital mortality, despite being the
focus of medical research and public health initiatives for several years. The primary …

Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute
kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse …

Sepsis-induced acute kidney injury (S-AKI) is one of the most serious life-threatening
complications of sepsis. The pathogenesis of S-AKI is complex and there is no effective …