Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …

Understanding the mechanisms of fibrotic transformation in sarcoidosis enhances clinical
care and facilitates development of novel therapeutic options. The impact of these findings in …

Rationale: Genetic variation plays a significant role in the etiology of sarcoidosis. However,
only a small fraction of its heritability has been explained so far. Objectives: To define further …

Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology. A minority of
patients with sarcoidosis develop sarcoidosis-associated pulmonary fibrosis (SAPF), which …

Sarcoidosis is a rare disease of isolated or diffuse granulomatous inflammation. Although
any organs can be affected by sarcoidosis, cardiac sarcoidosis is a fatal disorder, and it is …

Patients with sarcoidosis undergo spontaneous remission or may be effectively controlled
with glucocorticoids alone in many cases. Progressive and refractory pulmonary sarcoidoisis …

Sarcoidosis may progress to pulmonary fibrosis in 5% of patients with significantly increased
mortality. Histopathology shows fibrosis in a lymphangitic pattern surrounding the …

Background Angiogenesis is an important process involved in the pathogenesis of diffuse
parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of …

MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression. In
sarcoidosis, aberrant miRNA expression may enhance immune responses mounted against …

Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is
believed to be caused by exposure to pathogenic antigens in genetically susceptible …