Since its inception in 1995, the biopharmaceutical classification system (BCS) has become
an increasingly important tool for regulation of drug products world-wide. Until now …

This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …

Food-drug interactions can be associated with alterations in the pharmacokinetic and
pharmacodynamic profile of various drugs that may have clinical implications. The various …

Age-related changes in pharmacokinetics principally affect drug absorption, distribution,
metabolism and elimination. Changes in pharmacodynamics are primarily seen in the …

Objective We investigated the effect of polymorphisms in the P‐glycoprotein (P‐gp) MDR1
gene on steady‐state pharmacokinetics of digoxin in Caucasians. According to earlier data …

Plasma binding protein levels are lower in the newborn than in the adult and gradually
increase with age. At birth, human serum albumin (HSA) concentrations are close to adult …

Aims A clinically important interaction between the cardiac glycoside digoxin and the
antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to …

Grapefruit juice produces mechanism‐based inhibition of intestinal drug metabolism when
consumed in normal quantities. This can produce clinically important increases in oral drug …

Patients with acid‐related diseases often need to take multiple medications. Treatment of
Helicobacter pylori infection often includes either a histamine type 2 (H2)‐receptor …

Aims A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C> T of the highly
polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction …