The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …

Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction (EAD) and graft failure. The mechanism of …

Neutrophils are the most abundant type of leukocytes with diverse functions in immune
defense including production of reactive oxygen species, bacteriocidal proteins, neutrophil …

Abstract Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury
but also required for the induction of the stress response that limits tissue injury and …

Platelets are one of the key mediators in thrombosis as well as in the progression of many
diseases. An increase in platelet activation and a decrease in platelet count is associated …

Background/Aim: Severe sepsis is associated with high morbidity and mortality rates.
Inflammation and coagulation play pivotal roles in the pathogenesis of sepsis leading to …

Importance Ischemia-reperfusion injury during hepatic resection has been shown to
accelerate progression of liver cancer. However, the prognostic relevance of remnant liver …