Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …

Synchronized crosstalk between the embryo and endometrium during the periconception
period is integral to pregnancy establishment. Increasing evidence suggests that the …

Abstract Methionine adenosyltransferase II (MAT2A) is essential to the synthesis of S-
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of
purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding …

To assess hepatotoxicity and to determine the underlying mechanisms of carbamazepine
(CBZ) toxicity in fish, histopathology and the liver proteome were examined after Chinese …

Objectives Early pregnancy loss is a major clinical concern in animal and human
reproduction, which is largely influenced by embryo implantation. The importance of …

Undifferentiated spermatogonia eventually differentiate in the testis to produce haploid
sperm. Within this cell population, there is a small number of spermatogonial stem cells …

One-carbon metabolism is a key metabolic network that integrates nutritional signals with
embryonic development. However, the response of one-carbon metabolism to methionine …