Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants
AB Moreno, AE Martínez de Alba, F Bardou… - Nucleic Acids …, 2013 - academic.oup.com
Eukaryotic RNA quality control (RQC) uses both endonucleolytic and exonucleolytic
degradation to eliminate dysfunctional RNAs. In addition, endogenous and exogenous …
degradation to eliminate dysfunctional RNAs. In addition, endogenous and exogenous …
[HTML][HTML] The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels
AA Pai, CE Cain, O Mizrahi-Man, S De Leon… - 2012 - journals.plos.org
Recent gene expression QTL (eQTL) mapping studies have provided considerable insight
into the genetic basis for inter-individual regulatory variation. However, a limitation of all …
into the genetic basis for inter-individual regulatory variation. However, a limitation of all …
[PDF][PDF] Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD
Summary SMG1, a PI3K-related kinase, plays a critical role in nonsense-mediated mRNA
decay (NMD) in mammals. SMG1-mediated phosphorylation of the UPF1 helicase is an …
decay (NMD) in mammals. SMG1-mediated phosphorylation of the UPF1 helicase is an …
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans
D Longman, N Hug, M Keith, C Anastasaki… - Nucleic acids …, 2013 - academic.oup.com
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons but also regulates the abundance of cellular RNAs …
harboring premature termination codons but also regulates the abundance of cellular RNAs …
[HTML][HTML] Statistical modeling of RNA-Seq data
Recently, ultra high-throughput sequencing of RNA (RNA-Seq) has been developed as an
approach for analysis of gene expression. By obtaining tens or even hundreds of millions of …
approach for analysis of gene expression. By obtaining tens or even hundreds of millions of …
Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function
Advances in high-throughput mass spectrometry are making proteomics an increasingly
important tool in genome annotation projects. Peptides detected in mass spectrometry …
important tool in genome annotation projects. Peptides detected in mass spectrometry …
Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity
JD Laver, X Li, K Ancevicius, JT Westwood… - Nucleic acids …, 2013 - academic.oup.com
Despite studies that have investigated the interactions of double-stranded RNA-binding
proteins like Staufen with RNA in vitro, how they achieve target specificity in vivo remains …
proteins like Staufen with RNA in vitro, how they achieve target specificity in vivo remains …
Tissue-specific regulation of gene expression via unproductive splicing
A Mironov, M Petrova, S Margasyuk… - Nucleic Acids …, 2023 - academic.oup.com
Eukaryotic gene expression is regulated post-transcriptionally by a mechanism called
unproductive splicing, in which mRNA is triggered to degrade by the nonsense-mediated …
unproductive splicing, in which mRNA is triggered to degrade by the nonsense-mediated …
mRNA Editing, Processing and Quality Control in Caenorhabditis elegans
While DNA serves as the blueprint of life, the distinct functions of each cell are determined
by the dynamic expression of genes from the static genome. The amount and specific …
by the dynamic expression of genes from the static genome. The amount and specific …
[HTML][HTML] Non-coding functions of alternative pre-mRNA splicing in development
S Mockenhaupt, EV Makeyev - Seminars in cell & developmental biology, 2015 - Elsevier
A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo
alternative splicing to generate more than one mature product. By targeting the open …
alternative splicing to generate more than one mature product. By targeting the open …