Although most treatment algorithms in inflammatory bowel disease (IBD) begin with
classifying patients according to disease severity, no formal validated or consensus …

Ulcerative colitis is a common chronic inflammatory disease of the colon and rectum,
resulting from a dysregulated immune response towards intraluminal antigens in a …

Introduction A dysregulated intestinal T cell response is presumed in patients with
inflammatory bowel disease [IBD]. In this longitudinal study, we investigated the changes in …

Inflammatory bowel diseases have a natural course characterized by alternating periods of
remission and relapse. Disease flares occur in a random way and are currently …

Background and aim Disease activity for Crohn's disease (CD) and UC is typically defined
based on symptoms at a moment in time, and ignores the long-term burden of disease. The …

Background & Aims In patients with inflammatory bowel diseases, the combination of
infliximab and thiopurines (such as 6-thioguanine) is more effective treatment than …

Background Psychological morbidity in young people aged 10–24 years, with inflammatory
bowel disease (IBD) is increased, but risk factors for and impacts of this are unclear. Aim To …

Purpose of review This article reviews current treatment options and strategies and provides
an update on the status of drug development programs of new therapeutic agents for …

Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA)
occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the …

Crohn's disease is a chronic, progressive, destructive disease. Complicated disease can be
defined as the presence of bowel damage (stricture, abscess or fistula) and/or the need for …