[HTML][HTML] Natural killer cells: In health and disease

A Mandal, C Viswanathan - Hematology/oncology and stem cell therapy, 2015 - Elsevier
Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against
tumors and launching attacks against infections. The activities of NK cells are regulated by …

Role of chemokines in the biology of natural killer cells

MJ Robertson - Journal of leukocyte biology, 2002 - academic.oup.com
Natural killer (NK) cells participate in innate and adaptive immuneresponses to obligate
intracellular pathogens and malignant tumors. Twomajor NK cell subsets have been …

Expansion of highly cytotoxic human natural killer cells for cancer cell therapy

H Fujisaki, H Kakuda, N Shimasaki, C Imai, J Ma… - Cancer research, 2009 - AACR
Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. The
development of clinically applicable methods to produce large numbers of fully functional …

Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells

C Imai, S Iwamoto, D Campana - Blood, 2005 - ashpublications.org
Natural killer (NK) cells hold promise for improving the therapeutic potential of allogeneic
hematopoietic transplantation, but their effectiveness is limited by inhibitory HLA types. We …

Chimeric receptors with 4-1BB stimulatory signaling domain

D Campana, C Imai - US Patent 8,399,645, 2013 - Google Patents
The present invention relates to a chimeric receptor capable of signaling both a primary and
a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway with out …

Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications

N Lapteva, AG Durett, J Sun, LA Rollins, LL Huye… - …, 2012 - Taylor & Francis
Background aims. Interest in natural killer (NK) cell-based immunotherapy has resurged
since new protocols for the purification and expansion of large numbers of clinical-grade …

CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor

BORREGO, ROBERTSON, RITZ, PEÑA… - Immunology, 1999 - Wiley Online Library
CD69 is a differentiation antigen expressed shortly after activation on T lymphocytes and
other cells of haematopoietic origin, including natural killer (NK) cells. The function of CD69 …

[HTML][HTML] Generating natural killer cells for adoptive transfer: expanding horizons

S Kundu, M Gurney, M O'Dwyer - Cytotherapy, 2021 - Elsevier
Natural killer (NK) cells are unique innate lymphoid cells that have therapeutic potential in
adoptive cell transfer-based cancer immunotherapy that has been established across a …

Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide

MH Saleh, I Rashedi, A Keating - Frontiers in immunology, 2017 - frontiersin.org
Traditional uses of herbal medicine have depended mostly on anecdotal evidence for much
of history. The increasing application of scientific rigor to the study some of these traditional …

Expansion and activation of natural killer cells for cancer immunotherapy

D Cho, D Campana - The Korean journal of laboratory …, 2009 - synapse.koreamed.org
Natural killer (NK) cells can kill a wide range of cancer cells and are a promising tool for cell
therapy of cancer. NK cells cytotoxicity is regulated by a balance between stimulatory and …