[HTML][HTML] Sleep disorders and Alzheimer's disease pathophysiology: The role of the Glymphatic System. A scoping review

K Astara, A Tsimpolis, K Kalafatakis… - Mechanisms of Ageing …, 2023 - Elsevier
Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

The Brain Endothelial Cell Glycocalyx Plays a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 …

MR Hayden - Life, 2023 - mdpi.com
The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a
complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound …

A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

MR Hayden - Biomedicines, 2024 - mdpi.com
The recently described perivascular unit (PVU) resides immediately adjacent to the true
capillary neurovascular unit (NVU) in the postcapillary venule and contains the normal …

Protoplasmic Perivascular Astrocytes Play a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes …

MR Hayden - Neuroglia, 2023 - mdpi.com
Astrocytes (ACs) are the most abundant cells in the brain and, importantly, are the master
connecting and communicating cells that provide structural and functional support for brain …

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood–Brain Barrier Dysfunction/Disruption with Increased Risk of …

MR Hayden - Biomedicines, 2024 - mdpi.com
Globally, cerebral microbleeds (CMBs) are increasingly being viewed not only as a marker
for cerebral small vessel disease (SVD) but also as having an increased risk for the …

Association between enlarged perivascular spaces in basal ganglia and cerebral perfusion in elderly people

S Wang, S Yang, D Liang, W Qin, L Yang, X Li… - Frontiers in …, 2024 - frontiersin.org
Background and objective Enlarged perivascular spaces in basal ganglia (BG-EPVS) are
considered an imaging marker of cerebral small vessel disease (CSVD), but its …

Nonintuitive Immunogenicity and Plasticity of Alpha-Synuclein Conformers: A Paradigm for Smart Delivery of Neuro-Immunotherapeutics

A Abioye, D Akintade, J Mitchell, S Olorode, A Adejare - Pharmaceutics, 2024 - mdpi.com
Despite the extensive research successes and continuous developments in modern
medicine in terms of diagnosis, prevention, and treatment, the lack of clinically useful …

Pericytes and Resident Perivascular Macrophages Play a Key Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome and Type 2 …

MR Hayden - 2023 - preprints.org
Pericyte (s)(Pcs) and resident perivascular macrophages (rPVMΦs) are positioned perfectly
in the neurovascular unit (NVU) and perivascular spaces to facilitate metainflammation that …